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Exercise Can Alleviate Depression

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Exercise Can Alleviate Depression

The CDC reports that more than 1 in 9 Americans over age 12 take an antidepressant – and 60% will be on it for 2 years or more. Yet, several studies have shown that moderate exercise can be as effectiveas taking an antidepressant for mild to moderate depression.

You don’t have to be a fitness guru – just walking for 35 minutes, 6 days each week lowered mild to moderate depression by 47%.

Why? A recent study in the New England Journal of Medicine (Dec 11, 2014) may have the answer:kynurenine.

In the absence of exercise, stress greatly increases production of kynurenine in the liver, spleen and monocytes (a type of white blood cell). Kynurenine finds its way into the bloodstream and brain, resulting in inflammation and free radicals that influence brain metabolism and behavior that leads to depression.

When you are stressed and you exercise, your muscles produce enzymes called KATs or kynurenine aminotransferases that metabolize the kynurenine. The byproduct (kynurenic acid) can’t get from the blood stream into the brain. That creates resilience to stress.

This is of particular importance in menopausal women and those with type 2 diabetes, when kynurenine levels are typically higher.
Dr. Mache Seibel, Founder of My Menopause Magazine http://bit.ly/MyMenoMag
Professor, University of Massachusetts Medical School
Founder My Menopause Magazine

PS: Find more information of this type in My Menopause Magazine, available for the iPad in the Apple Newsstand. http://bit.ly/MyMenoMag


“It’s better to stay well than to get well!”  Mache Seibel, MD.

Dr. Machelle (Mache) Seibel is America’s health expert, addressing the critical needs of consumers from stress and weight control to menopause and beyond. He served on the Harvard Medical School faculty for almost 20 years and is a pioneer in many areas of women’s health and more. He works with companies and organizations to bring exciting educational content to consumers. His professional experiences include:

– Host for PBS and NBC TV episodes, frequent media expert;

– Repeatedly voted into Best Doctors in America;

– Past Editor-in-Chief of the medical journal Sexuality, Reproduction & Menopause;

– Distinguished Alumnus Award, the University of Texas Medical Branch’s highest honor 2008;

– Multiple national awards for research, writing, music writing and patient education;

– Professor, University of Massachusetts Medical School 2004-present;

– Director, Complicated Menopause Program, University of Massachusetts Medical School 2004-2011;

– Founder of HealthRock®, reshaping health education with health songs and entertainment;

– Past Medical Director, Inverness Medical Innovations (now Alere);

– Corporate Consultant and Corporate Health Expert Nationally and Internationally;

– Author/editor 14 books, over 200 scientific articles;

– American Cancer Society New England Division Medical Advisory Network;

– Advisory board of Dr. Mehmet Oz’s HealthCorps initiative to fight childhood obesity; and

– Nationally known guest speaker, key note speaker.

Visit his award-winning website www.DoctorSeibel.com and sign up for his free monthly newsletter.

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